解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
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神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
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公共、环境和职业卫生
放射学,核医学和医学成像
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生殖生物学
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外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Naïve CD8(+) T cells differentiate into effectors secreting various cytokines that modulate immune functions. A striking finding for most HIV-1-infected patients is that they accumulate CD8(+) T cells belonging to early and intermediate differentiated elements. Structural HIV-1 proteins, and among these the matrix pro...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2007.0095
更新日期:2008-06-01 00:00:00
abstract::In this study we investigated the efficacy of a multigenic DNA prime/modified vaccinia Ankara (MVA)boost vaccine approach, followed by mucosal challenge with highly pathogenic simian-human immunodeficiency virus (SHIV) 89.6P, using different routes for vaccine delivery. After three times of DNA priming (SIVmac239, Gag...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2007.0103
更新日期:2008-06-01 00:00:00
abstract::Severe acute respiratory syndrome (SARS) is a deadly and highly infectious disease caused by SARS Coronavirus (SARS-CoV). Inactivated SARS-CoV has been explored as a vaccine against SARS-CoV; however, current knowledge of inactivated SARS-CoV vaccine is quite limited. We attempted to investigate the effects of differe...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2007.0079
更新日期:2008-03-01 00:00:00
abstract::We investigated the duration of humoral responses to dengue virus infection in individuals who recalled experiencing dengue fever-like illnesses at the time of the Second World War, when dengue fever epidemics occurred throughout the Pacific and Southeast Asia. In July 1943 dengue fever reappeared in Hawaii following ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2007.0050
更新日期:2007-12-01 00:00:00
abstract::Mannan-binding lectin (MBL) is a collectin that mediates activation of the complement system and is of importance for host defenses. In humans low concentrations of MBL in serum have been associated with susceptibility to several viral diseases. To understand the function of MBL in relation to infectious viral disease...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2007.0036
更新日期:2007-12-01 00:00:00
abstract::To warrant potential clinical testing, the equine anti-severe acute respiratory syndrome coronavirus (SARS-CoV) F(ab')(2) requires evaluation in as many animal models as possible. In this study, we established a new animal model, the Chinese hamster, susceptible to SARS-CoV infection. SARS-CoV could propagate effectiv...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2007.0038
更新日期:2007-09-01 00:00:00
abstract::Virus-specific cytotoxic T lymphocytes (CTLs) are crucial for the control of respiratory syncytial virus (RSV) infection. This study has identified CTL epitopes of the RSV N protein in healthy subjects. We screened the primary structure of the N protein for HLA-A 0201-binding amino acid consensus motifs, identifying t...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2007.0041
更新日期:2007-09-01 00:00:00
abstract::Exposure to environmental contaminants has a profound effect on immune function, yet mechanistic understanding of how pollutants deregulate immune responses has, for many chemicals, remained elusive. Available data suggest that certain pollutants alter host immune responses and increase susceptibility to viral infecti...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2007.0013
更新日期:2007-07-01 00:00:00
abstract::Given the continued spread of human immunodeficiency virus (HIV)-1 worldwide, developing efficient vaccine strategies against HIV-1 is a key task. We tested the safety and immunogenicity of a multicomponent, cell-based vaccine that consisted of antigen-expressing apoptotic bodies with or without autologous dendritic c...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2006.0052
更新日期:2007-04-01 00:00:00
abstract::Anogenital warts are a common clinical manifestation of genital infection with human papillomavirus type 6b (HPV-6b). Accumulating data indicate that an effective cellular immune response is required for the control of HPV infections. However, in a minority of patients there is a high rate of recurrence of wart lesion...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2006.0065
更新日期:2007-04-01 00:00:00
abstract::To study IgG-specific subclasses of hepatitis B virus (HBV) surface antigen (anti-HBs), in different populations in Taiwan, a comparison was made between 104 chronic carriers (60 male and 44 female) and 439 recovered individuals (247 male and 192 female). Biochemical analyses of aspartate aminotransferase (AST) and al...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2006.19.277
更新日期:2006-07-01 00:00:00
abstract::HIV-1 p17 is a viral cytokine that acts on preactivated, but not on resting, human T cells promoting proliferation, proinflammatory cytokines release and HIV-1 replication, after binding to a cellular receptor (p17R). Here, we demonstrate that p17Rs are expressed on activated murine T cells, which respond to p17 stimu...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2006.19.177
更新日期:2006-07-01 00:00:00
abstract::To improve efficacy, especially for the cell-mediated response to inactivated viral vaccines, a modified levamisole (LMS) adjuvant formulation, designated LMS+, was evaluated for its efficacy in mice and chickens, using Newcastle Disease Virus (NDV) as a model pathogen. Compared with oil adjuvant, the killed NDV in LM...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2006.19.525
更新日期:2006-07-01 00:00:00
abstract::Chemokine receptors CXCR4 and CCR5 play a key role in Human Immunodeficiency Virus (HIV) entry into CD4+ monocytic cells. Alteration in the expression levels of these receptors by immunoregulatory cytokines may influence viral entry and hence susceptibility to HIV infection, viral tropism, and disease progression. Hel...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2006.19.409
更新日期:2006-07-01 00:00:00
abstract::A 90-amino acid peptide from the simian rotavirus SA-11 nonstructural protein, NSP4 was linked to the N-terminus of the Ricinus communis A-B toxin B subunit protein (RTB) and synthesized in Escherichia coli. Recombinant RTB and the NSP4(90)::RTB fusion protein bound artificial receptor glycoprotein asialofetuin in an ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2006.19.54
更新日期:2006-04-01 00:00:00
abstract::This study was aimed at investigating the genes that control host responses to Marek's disease virus (MDV). Spleen tissues from infected and age-matched uninfected control chickens were examined 4, 7, 14, and 21 d postinfection for gene expression differences, using both microarray and quantitative real-time polymeras...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2006.19.747
更新日期:2006-01-01 00:00:00
abstract::The ability of porcine reproductive and respiratory syndrome virus (PRRSV) to suppress T cell expression of CD25 (alpha chain of interleukin [IL]-2 receptor), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) was determined by flow cytometry in naive porcine T cells in response to mitogen (conc...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2006.19.646
更新日期:2006-01-01 00:00:00
abstract::Although field studies have found porcine reproductive and respiratory syndrome (PRRSV) inactivated vaccines to be beneficial in reducing losses linked to PRRSV infection, immune mechanisms induced by these vaccines need better understanding. In the study reported here, we examined the interferon-gamma(+) (IFNgamma(+)...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2005.18.381
更新日期:2005-01-01 00:00:00
abstract::Adenoviral vector has been extensively studied as a vaccine platform because of its ability to induce potent cellular and humoral immunity. One main advantage of adenoviral vectors is their natural tropism for mucosal surfaces, which makes them ideal for the purpose of mucosal vaccination against pathogens that prefer...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2005.18.283
更新日期:2005-01-01 00:00:00
abstract::One of the strategies that has been investigated to reduce antiretroviral treatment toxicity in patients infected with human immunodeficiency virus (HIV) is structured treatment interruption (STI). Our aim was to analyze early viral and immune dynamics after interruption of highly active antiretroviral therapy (HAART)...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2005.18.740
更新日期:2005-01-01 00:00:00
abstract::Current treatments for hepatitis C infection have limited efficacy, and there is no vaccine available. The goal of this study was to compare the immune response to several immunization combinations against hepatitis C virus (HCV). Six groups of mice were immunized at weeks 0, 4, and 8 with different combinations of a ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2005.18.637
更新日期:2005-01-01 00:00:00
abstract::Antigen-primed cytotoxic T lymphocytes (CTL) may express leukocyte immunoglobulin-like receptors (LILRs) and natural killer receptors (NKRs). Published work suggests that expression of some of these receptors confers survival advantage, leading to the idea that cells expressing such receptors may accumulate as an anti...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2005.18.513
更新日期:2005-01-01 00:00:00
abstract::Regulatory/suppressor cells have become rehabilitated and respectable. They returned as regulators of autoimmunity, but are now acknowledged to critically influence immunity to foreign antigens, such as those found on microbes. This review describes the principal types of regulatory cells that influence immunity to mi...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2005.18.411
更新日期:2005-01-01 00:00:00
abstract::We have previously demonstrated the formation and release of influenza virus-like particles (VLPs) from the surface of Sf9 cells infected with either a quadruple baculovirus recombinant that simultaneously expresses the influenza structural proteins hemagglutinin (HA), neuraminidase (NA), matrix 1 (M1) and M2, or a co...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2005.18.244
更新日期:2005-01-01 00:00:00
abstract::The JHM strain of mouse hepatitis virus (JHMV) is rapidly cleared from the central nervous system (CNS) by CD8(+) T cells. In the absence of CD4(+) T cells, fewer CD8(+) T cells are found within the CNS in association with a coordinate increase in apoptotic lymphocytes. Previous data suggested that CD4(+) T cells may ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2005.18.162
更新日期:2005-01-01 00:00:00
abstract::Astroviruses are one of the leading causes of acute viral enteritis in infants, and are recognized as a clinically important pathogen in the elderly and the immunocompromised. In spite of this, we still know very little about the immune response to astrovirus infection. Clinical observations and human volunteer studie...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2005.18.11
更新日期:2005-01-01 00:00:00
abstract::Sera from 1003 in- and out-patients were investigated for hepatitis B surface antigen (HBsAg) mutation at Siriraj Hospital, Bangkok, Thailand. Individual samples were screened using two commercial HBsAg kits on automatic machine-based assays set up in parallel. The first kit was a sandwich ELISA kit that used monoclon...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2004.17.440
更新日期:2004-01-01 00:00:00
abstract::Transmissible spongiform encephalopathies are fatal neurodegenerative disorders that include Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy and scrapie in sheep and goats. Transmissible spongiform encephalopathies are thought by some to result from changes in the conformation of a membrane glyco...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2004.17.334
更新日期:2004-01-01 00:00:00
abstract::Findings coming from autopsies and serum of SARS patients suggest an important immune-inflammatory implication in the evolution to respiratory distress. Conditions such as HIV infection or treatment with immunosuppressors (in cancer or autoimmune diseases) are not among the bad prognosis factors for development of dis...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2004.17.535
更新日期:2004-01-01 00:00:00
abstract::The objective of this study was to investigate the immune responses elicited by either a modified-live (MLV) or a killed virus (KV) porcine reproductive and respiratory syndrome virus (PRRSV) vaccine. Specifically, we investigated the effects of multiple vaccinations on antigen-specific cellular and antibody responses...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/088282404322875430
更新日期:2004-01-01 00:00:00
abstract::Interferon (IFN) can activate Signal Transducer and Activator of Transcription (STAT) proteins to establish a cellular antiviral response and inhibit virus replication. Many viruses have evolved strategies to inhibit this antiviral mechanism, but paramyxoviruses are unique in their abilities to directly target the IFN...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/0882824041310568
更新日期:2004-01-01 00:00:00
abstract::The cytokine profile associated with either a T helper 1 (Th1) or Th2 response in a porcine respiratory disease model was assessed by measuring IL-12, IL-10 and IFN-gamma using RT-PCR and ELISA, respectively. IL-10, IL-12, and IFN-gamma levels in pulmonary alveolar macrophages and bronchial lavage fluid were increased...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/088282403322396154
更新日期:2003-01-01 00:00:00
abstract::Infection with a murine retrovirus, MoMuLV-TB, ts1 in BALB/c mice has been established as a small animal model for retroviral neurodegenerative disease as shown with infections such as HIV. However, mother-to-pup transmission has never been demonstrated in this model. The current investigation examines vertical transm...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/088282403322017929
更新日期:2003-01-01 00:00:00
abstract::In general, virus-specific antibodies are considered antiviral and play an important role in the control of virus infections in a number of ways. However, in some instances, the presence of specific antibodies can be beneficial to the virus. This activity is known as antibody-dependent enhancement (ADE) of virus infec...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/088282403763635465
更新日期:2003-01-01 00:00:00
abstract::As popular strategies used by numerous viruses, interception of interferon (IFN) signaling and inhibition of IFN-induced antiviral functions allow viruses to evade the host immune response and set up successful infections. Hepatitis C virus (HCV), the leading cause of chronic liver disease worldwide and a major public...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/088282402317340260
更新日期:2002-01-01 00:00:00
abstract::Hantavirus nucleocapsid protein (N) has been proven to induce highly protective immune responses in animal models. The knowledge on the mechanisms behind N-induced protection is still limited, although recent data suggest that both cellular and humoral immune responses are of importance. For a detailed B-cell epitope ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/088282402317340323
更新日期:2002-01-01 00:00:00
abstract::Expression of the high-affinity interleukin 2 receptor alpha chain (CD25) was used to monitor antigen-specific activation of T lymphocyte subsets (CD4+, CD8+, and gammadelta T cells) from cattle immunized with modified live bovine herpesvirus-1 (BHV-1). Calves seronegative for BHV-1 were either vaccinated with one dos...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/08828240260066305
更新日期:2002-01-01 00:00:00
abstract::IFN-gamma is released in the brain, not only during acute infectious diseases or immunological reactions, but also for extended periods of time after clearance of infectious virus and during viral latency. In this review, we focus on the role of IFN-gamma in the interaction between a neuron and a pathogen, that is, th...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/08828240260066206
更新日期:2002-01-01 00:00:00
abstract::Cholangiocarcinoma is a malignancy of the biliary duct system. Presently, these malignant biliary tract diseases are common among the people in Southeast Asia, with the world's highest prevalence in northeastern Thailand and Laos. This carcinoma tends to grow slowly and to infiltrate the walls of the ducts, dissecting...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/088282402320914593
更新日期:2002-01-01 00:00:00
abstract::Previously, we have shown that bovine herpesvirus 1 (BHV-1) down-regulates the expression of major histocompatibility complex class I molecules by interfering with transport of peptides by the transporter associated with antigen processing (TAP). Further studies revealed that BHV-1 down-regulates the expression of mRN...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/088282402320914539
更新日期:2002-01-01 00:00:00